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Elevated serum copper levels are often observed in these patients due to the release of copper-containing enzymes after myocardial injury or because sympathetic nerves promote the release of copper from liver stores into the bloodstream during stress (54)

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But again, there are two main populations: cholinergic neurons and vasoactive intestinal peptide (VIP)-expressing, noncholinergic neurons (TABLES 1 AND 2)

Interestingly, Sderholm's group in Sweden showed that the TEER and the paracellular passage of 51 Cr-EDTA and FD4 are not altered in the sigmoid colon of UC patients in remission but they have an increased transepithelial flux of the protein antigen HRP

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Hence, some conceptual and methodological problems must be addressed and new methods critically evaluated