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Avoid drugs that affect the methylation cycle: Antacids (deplete B12) Cholestyramine (deplete cobalamin and folate absorption) Colestipol (decrease cobalamin and folate absorption) Methotrexade (inhibits DHFR) Nitrous oxide (inactivates MS) High dose Niacin (depletes SAMe and limits pyridoxal kinase active B6) Theophylline (limits pyridoxal kinase = active B6) Cyclosporin A (decreases renal function and increases Hcy) Metformin (decreases cobalamin absorption) Phenytoin (folate antagonist) Oral contraceptives (deplete folate) Antimalarials JPC-2056, Pyrimethamine, Proguanil (inhibits DHFR) Antibiotic Trimethoprim (inhibits DHFR) Ethanol (depletes folate and cobalamin) Bactrim (inhibits DHFR) Sulfasalazine (inhibits DHFR) Triamterene (inhibits DHFR) Avoid drugs that raise homocysteine levels

Targeting autophagy with natural compounds in cancer: a renewed perspective from molecular mechanisms to targeted therapy

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Customized steady-state constraints for parameter estimation in non-linear ordinary differential equation models

Mechanistic insight from broader reviews of antioxidant systems Lu, Y., et al