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METHODS We assessed the activated bypassing pathways between the inferior and superior caval veins and portocaval shunt, counteracted caval/portal hypertension, aortal hypotension, venous/arterial thrombosis, electrocardiogram disturbances, liver and gastrointestinal lesions ( i.e ., stomach and duodenum hemorrhages, in particular, congestion)

Beyond its well-known neurological manifestations, a significant proportion of MS patients experience gastrointestinal (GI) symptoms, particularly fluctuation between constipation and fecal incontinence, suggesting broader systemic involvement ( The gut-brain axis encompasses the bidirectional communication network established between the GI tract and the CNS, mediated through hormonal, neural, metabolic, and immunological pathways ( Faecalibacterium , Parabacteroides , Bifidobacterium , Prevotella ) and an increase in pro-inflammatory taxa such as Ruminococcus and Methanobrevibacter ( A growing body of evidence from both clinical and preclinical studies has firmly established a role for the gutbrain axis in the demyelination process of MS ( These findings support a functional gutimmunebrain communication axis, whereby intestinal microbial and immune alterations may directly modulate neuroinflammatory responses

149 Resveratrol is a natural SIRT1 activator

Pre-warmed Black Gold II solution was added onto sections and incubated at 60C

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In 712% of patients, heterozygous GBA1 mutations have been identified as the most prevalent genetic risk factors for PD [229]