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The underlying molecular mechanisms involve direct ROS-induced oxidative damage to neuronal lipids, proteins and DNA [331], as well as ROS-mediated oxidative modifications that crucially promote the aberrant aggregation of toxic proteins [332]

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For instance, RNA-seq technology was used to screen fatty acid transporter candidate genes such as CD36, SLC27A1 , and FABP3 , whose differential expression may affect fatty acid composition (9)

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