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By inhibiting the production of isoprenoids from the mevalonate pathway, statins prevent the activation of the ras homolog gene family, member A (RhoA)/rho-associated protein kinase (ROCK) in renal macrophages, thereby reducing the assembly of the NLRP3 inflammasome and subsequent production of IL-1/IL-18 (121, 122)

doi: 10.1002/ptr.8217 42 YaoY-XYuY-JDaiSZhangC-YXueX-YZhouM-Let al

10.3390/molecules23102583 32 de JuanesS.EppN.LatzkoS.NeumannM.FurstenbergerG.HausserI.et al (2009)

24:e55593

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While NAC helps build glutathione stores, direct glutathione supplementation with advanced absorption technology can support neuroprotection and mental clarity more efficiently