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PMID: 28696491
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The protective variant at rs2304256 was shown to decrease STAT1 phosphorylation in B lymphoblastoid cell lines when stimulated with IFN (67)
This process interferes with the necessary areas receiving many of the benefits of a pill, weakening its total effect
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Together, these pathways are of interest in models evaluating energy expenditure , mitochondrial stress adaptation, and body-composition endpoints
