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Yu J, Diao X, Zhang X, Chen X, Hao X, Li W, et al

Complementary strategies include convection-enhanced delivery (CED) systems that enhance parenchymal drug distribution and chemical modifications (e.g., lipid group conjugation) to improve drug lipophilicity for BBB transit [109, 110]

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Glutathione itself is converted from its oxidized form (GSSG) to its reduced form (GSH) by dedicated enzymes localized in the cytosol or mitochondria, which require NADPH as cofactor

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For instance, 4-HNE and oxidized phosphatidylethanolamines derived from ferroptotic glioblastoma cells upregulate IL-12 and TNF- in infiltrating macrophages, a feature not observed in hepatoma or colorectal models [153]