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Conclusion: NTZ exerted a hepatoprotective effect in MTX-challenged rats that is mediated via modulation of ER stress and inhibiting apoptosis

Roth JA, Grammer SF, Swisher SG , Nemunaitis J, Merritt J, Meyn RE Jr

Drugs Affecting Homocysteine Metabolism

Funding: The author(s) received no financial support for the research, authorship and/or publication of this article

doi: 10.1158/0008-5472.CAN-18-1604

It is also involved in cholesterol levels.[ref] Genetic variants in the methylation pathway, including MTHFR, are strongly linked to high homocysteine levels and heart disease in many studies
