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It also plays a role in energy homeostasis and cellular metabolism

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In fact, according to the National Institutes of Health, nearly 1 in 5 adults over 60 and up to 15% of the general population are estimated to be deficient in vitamin B12

Published preclinical data in rodents suggests doses equivalent to 200mg+ in humans produce off-target effects on folate metabolism and S-adenosylmethionine (SAMe) pools