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Future work should address if removal or substitution of certain drugs in the COJEC chemotherapy protocol could lead to better combinations

However, excessive iron accumulation leads to the generation of radicals through the Fenton reaction, which then interact with polyunsaturated fatty acids (PUFA) and cause ferroptosis [18]

Furthermore, vital signs and adverse events (AEs) were observed

Building sustainable diet strategies during and after medication use is key to long-term success

However, low or absent MGMT may not always be a predictor of TMZ response it has been shown that approximately 35% of aggressive PRLomas or PRL-secreting PC that progressed despite TMZ therapy presented with absent MGMT expression (213)

It is speculated that Glu-induced death and ferroptosis may share the same signaling pathway