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Persistent PHN usually requires reassessment of which anatomical structure is generating the pain, what process keeps it active, and which factors maintain nerve hypersensitivity

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For plant-based eaters, fortified cereals, nutritional yeast, and B12 supplements can help fill the gap

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[1] [2] However, longstanding neurological complications, such as peripheral neuropathy or cognitive changes, may require three to six months of consistent treatment before significant improvement occurs, and some damage may be irreversible if treatment is delayed

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Antibiotics, particularly tetracyclines, anticonvulsants like phenobarbital, and certain chemotherapy agents may interact negatively with the B vitamins

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