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Patients were divided into those who received an IL-6 inhibitor (sarilumab or tociluzimab) and those who did not

Co-transfection of cells with the EAAT3 promoter-driven luciferase reporters, specifically WT-luc, followed by treatment with TNF or co-transfection with P65, led to the activation of luciferase activity with the wild-type EAAT3 promoter (WT-TNF or WT-P65)

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Duration varies by dose, metabolism, and whether food was consumed at the time of dosing

It transfers electrons from complex I (NADH NAD+) and complex II (succinate fumarate) to complex III

1973 Sep;14(9):711-5