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130 This weak receptor binding and cellular activation capacity is likely due in part to the fact that IgG4 is often monovalent

Given that mitochondria are essential for tumorigenesis and cancer cell proliferation (3133), targeting the mitochondrial OXPHOS metabolic pathway may be a viable approach for inhibiting the growth of cancer cells (34)

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Design, synthesis, and evaluation of -phosphono diester analogues of glutamate as highly potent inhibitors and active site probes of -glutamyl transpeptidase