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doi: 10.3389/FBIOE.2022.1042128 109 MajiduddinF

These reports, while not scientifically rigorous, are numerous and consistent

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As well as causing B12 deficiency, an increase in methylmalonic acid occurs, which is thought to result in loss of myelin in the peripheral nerves and, consequently, neuropathy, which may be symptomatic as early as 2 years into metformin treatment

Nutritional deficiencies in vitamin C, K, or iron also impair blood vessel integrity and healing speed