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[1] Because intrinsic-factor-dependent uptake in the distal ileum can be absent in conditions such as autoimmune gastritis, pancreatic insufficiency, or bariatric surgery, the intramuscular or subcutaneous route bypasses gastrointestinal barriers and reliably restores serum concentrations

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Blood from the mesenteric veins that supply the gastrointestinal tract is collected by the portal venous system, which, together with the hepatic artery, supplies the liver, allowing alcohol metabolism to occur before the blood returns to the heart
