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Li, H., Xu, M., Lee, J., He, C

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There are many reports that describe the in vitro production of endodermal cell types from hPSCs: thymic epithelial cells 26,27,28 , pancreatic beta cells 29 , lung epithelial cells 30 , intestinal cells 31 , cholangiocytes 32,33,34,35 and hepatocytes 3,5,6,11,36,37,38

mtDNA leaked into the cytoplasm by mitochondria during stress is an important source of DAMPs, and cytoplasmic mtDNA binds to and activates different DNA pattern recognition receptors, inducing strong intrinsic immune responses (71) ( Figure 4 )

10.3390/ijms161025912

Furthermore, differences in the thermodynamic interaction dynamics contribute to distinct binding kinetics for each of the two motifs