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However, the relationship between internalization and loss of signaling capacity seemed influenced by the cell type and effector considered

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The identification of reliable validated biomarkers could facilitate earlier and more accurate diagnosis and drive the development of targeted pharmacological therapies that might address the underlying pathophysiology of these diseases

An evolutionary stress-response hypothesis for chronic widespread pain (fibromyalgia syndrome)
Combination with professional treatments becomes more valuable in this age group

doi: 10.1016/0361-9230(87)90069-4