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This is why anti-TNF biologics were among the first targeted therapies developed for psoriasis

Lithium: Bei gesunden Probanden wurde eine Reduktion der systemischen Lithium-Exposition (18% der AUC) whrend der gleichzeitigen Verabreichung von Topiramat 200 mg/Tag beobachtet

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however, this may result in loss of desired effects

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The Cumulative Effect: When Multiple Factors Combine Many people have multiple risk factors simultaneously