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At first the bodies of vegetarians and vegans did not produce much TMAO even when they took supplements, but after a few weeks they did, Hazens team reported in the Journal of Clinical Investigation. In Medical Express December 10, 2018 they reported, The findings suggest that measuring and targeting TMAO levelssomething doctors can do with a simple blood testmay be a promising new strategy for individualizing diets and helping to prevent heart disease

Enhanced purine/pyrimidine metabolites support RNA/protein synthesis and transcriptional reprogramming, which is promoted also by some fasting-related metabolites, possibly via epigenetic modulations