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The activated AR further enhances IRE1 expression, creating a positive feedback loop that promotes PCa proliferation [107]

Both GBCAs were intravenously injected with 2 mmol/kg into the mothers from E15 to E19, which is the critical period for the development of neuronal circuits in fetus

A 60% decline

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NRF2 controls many of the enzymes that participate in glutathione synthesis and metabolism, including the catalytic and regulatory subunits of glutamate-cysteine ligase (GCLC/GCLM), glutathione synthase (GSS) and the subunit of the cystine/glutamate transporter xCT (SLC7A11), all of which are required for glutathione synthesis (Kwak et al., 2002

Given the potential of ferroptosis as a target not just for cancer, but also for neurodegenerative and ischemic disease, further work to characterize tissue-specific changes could be instrumental for the development of a new generation of targeted therapies.