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CircABCA1 promotes ccRCC by reprogramming cholesterol metabolism and facilitating M2 macrophage polarization through IGF2BP3-mediated stabilization of SCARB1 mRNA

Observational study - a human research study in which no experimental intervention or treatment is applied, and participants are simply observed over time Oxidative stress - a situation in which the production of reactive oxygen species exceeds the ability of an organism to eliminate or neutralize them Placebo - a chemically inactive substance Plaque - a deposit of fat, cholesterol, immune cells, fibrin (a clotting protein), and other substances that forms inside arterial walls Randomized controlled trial - a human research study in which participants are assigned by chance alone to receive either an experimental agent (the treatment group) or a placebo (the control group) Reactive oxygen species (ROS) - highly unstable oxygen-containing compounds that react easily with nearby cellular structures, potentially causing damage Test tube - a research experiment performed in a test tube, culture dish, or other artificial environment outside of a living organism

Congrats to Branden Bean , Mikkiya Sloan , and Jaden Aguirre

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This study also reported that increased serum L-carnitine levels were associated with significantly more atherosclerotic plaque in the 2,595 people who underwent elective cardiac screening, but only in those whose TMAO levels were also elevated