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Importantly, there is accumulating evidence that suggests that HSV-1 infection of the brain both, in symptomatic and asymptomatic individuals could lead to neuronal damage and eventually, neurodegenerative disorders

doi: 10.1016/j.freeradbiomed.2008.07.006

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Downregulation of lactate metabolism inhibited the proliferation of lymphoma cells at the cellular level and in subcutaneous tumors, and overexpression of NDRG3 reversed the growth inhibition caused by downregulation of lactate metabolism

Even moderate vitamin B12 deficiency has been associated with demyelination and brain atrophy 3