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The elegant solution was combining glucagon activation with sufficient GLP-1 activity to counterbalance hyperglycemic potential
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Mechanistically, GLP-1 agonists appear to work by blocking VLDL production in the liver and activating lipoprotein lipase which results in better lipid profiles [36]
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If dietary measures are insufficient, over-the-counter fiber supplements (psyllium, methylcellulose) or osmotic laxatives (polyethylene glycol) may be appropriate after discussing with your healthcare provider
