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In contrast, GLP-1RAs@NPs-WYRGRL significantly suppressed the expression of IL-6, cGAS, STING and ACSL4 and enhanced the expression of GLP-1R in chondrocytes induced by LPS compared with the NPs-WYRGRL treatment group (Fig

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As of 2026, retatrutide holds no MHRA (Medicines and Healthcare products Regulatory Agency) marketing authorisation and is classed as an unlicensed investigational peptide in the UK [1][6]