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Mean weight loss was 8.0% at 56 weeks with liraglutide 3.0 mg vs 2.6% with placebo

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Each dose increase can temporarily worsen symptoms

More serious, though much rarer, risks have been identified, including a potential increased risk of pancreatitis and gallbladder problems

Alcohol use can cause symptoms of depression which will decrease the effectiveness of bupropion XL

41,42 In humans, heart rate increases following a meal, mediated by withdrawal of parasympathetic modulation of the heart (assessed by diminished HRV) and not by sympathetic activation