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Liu S., Wen Y., Shan X., et al., ChargeAssisted Stabilization of Lipid Nanoparticles Enables Inhaled mRNA Delivery for Mucosal Vaccination, Nature Communications 15 (2024): 9471

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A significant limitation of nasal drops is their imprecision in dosing when compared to other delivery devices, making them less suitable for medications that require strict dose accuracy (Tandel et al., 2011