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Working in India, Simeons reported that obese patients given HCG alongside a very-low-calorie diet seemed to lose fat rather than lean tissue, and he published his protocol in a book titled Pounds and Inches: A New Approach to Obesity

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The GLP-1 component simultaneously engages both central and peripheral receptors, influencing gastric emptying rates and hypothalamic signaling

A significant concern is the risk of acute kidney injury (AKI) if naproxen is taken during periods of dehydration from Wegovy-related vomiting or diarrhoea