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Description
Both groups maintained lifestyle interventions - 500-calorie daily deficit, 150 minutes weekly of physical activity
Nausea associated with GLP-1 receptor agonists is generally most pronounced during treatment initiation and following dose escalations, typically diminishing over the first few weeks as the body adapts
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Maintaining lean mass helps sustain resting energy expenditure, thereby facilitating weight loss and supporting long-term weight maintenance [25]

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The standard dose titration schedule for semaglutide and tirzepatide is designed to minimize side effects, and fatigued patients may benefit from being especially conservative about dose increases