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There is emerging evidence suggesting that GIP receptor activation has beneficial effects on glucose homeostasis, though historically it was challenging to target due to the complex nature of GIP action in type 2 diabetes

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To synthesize the findings discussed across different substance classes, Table 2 summarizes the neurobiological mechanisms by which GLP-1 receptor agonists modulate addiction-related behaviors in preclinical models

Clinically, GLP-1RAs could lead to an improvement in cognitive function, which is often found to be impaired across several conditions such as psychosis 240 and mood disorders 241 , eventually leading to an overall benefit as observed in some of the included studies (Tables 4 and 5)

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The EMA stated that NAION may affect up to 1 in 10,000 people taking semaglutide and recommended that semaglutide treatment be stopped if NAION is confirmed