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The researchers did not enroll any subjects with a history of epilepsy or seizure

Although brand names for the drugs such as Ozempic and Wegovy are becoming ever-more present in the American consciousness, awareness of the term GLP-1 remains low, especially when lacking context around weight loss

Discovery analysis: what did the study find

Maintaining lean muscle mass is important because muscle helps regulate metabolism and overall metabolic health

In fact, the omitted study was a pooled analysis of 5 RCTs 196,197,198,199,200 of 5,325 patients with obesity followed for up to 3 years, which had shown that liraglutide was no different from placebo for depressive symptoms as scored on the Patient Health Questionnaire-9, while also highlighting a small increased risk of suicidal behavior 193

If youre considering starting a GLP-1, be prepared for the possibility that this is a long-term medication, they advise