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In studies, after 52 weeks, participants on the highest dose of Mounjaro (15 mg per week): Lowered their total cholesterol by about 5.6 percent Lowered their triglycerides by 22.5 percent Lowered their LDL (bad) cholesterol by 7.9 percent Lowered their VLDL cholesterol by 21.8 percent Increased their HDL (good) cholesterol by 10.8 percent Additionally, a meta-analysis (analysis of data from several clinical trials) from The Lancet found that Ozempic lowered cardiovascular risk and even decreased the risk of death in people with diabetes and heart disease

After supply disruptions for semaglutide and tirzepatide ended, facilities continued producing glucagon-like peptide-1 receptor agonists (GLP-1 RAs) using compounded formulations that include added ingredients, according to a study published in JAMA Health Forum (doi:10.1001/jamahealthforum.2026.2207)

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