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This triple agonism distinguishes retatrutide from existing approved agents such as semaglutide (a GLP-1 receptor agonist) and tirzepatide (a dual GIP/GLP-1 agonist)

Endocrinology 146, 37483756

However, weight loss from semaglutide often reduces overall intra-abdominal pressure, potentially improving reflux long-term

Key Summary Prices are anticipated to fall 30-50 percent initially, with the potential for deeper cuts of up to 70-75 percent over time Dr Reddy's could be the first generic player among Indian companies to launch in Canada, and Sun Pharma in Brazil The launch of generic semaglutide is projected to boost overall Indian Pharmaceutical Market (IPM) growth by 0.5-1 percent The impending patent expiry of semaglutide drugs, used to treat diabetes and obesity, across India, emerging markets and select regulated markets such as Canada and Brazil, is expected to unlock a huge revenue opportunity, says a report

Patients with type 2 diabetes require alternative pharmacotherapy to maintain glycemic targets, while those using semaglutide for weight management benefit from structured lifestyle intervention programs to sustain weight loss
