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Clinical pharmacology biopharmaceutics review: Dulaglutide

GLP-1 receptor agonists were associated with markedly lower risks of major adverse cardiovascular events, progression of kidney disease, venous thromboembolism, and all-cause mortality compared to DPP-4 inhibitor therapy

But animal-to-human translation is imperfect

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This is likely a result of our NMA using a smaller set of studies to better reflect clinical practice, including only those which report on doses of semaglutide and liraglutide approved for weight management and excluding those using intensive behavioural therapy