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J Clin Endocrinol Metab

Direct effects come from GLP-1 receptor activity in the liver and gut, which reduces fat production and absorption independent of calorie intake

[DOI] [PMC free article] [PubMed] [Google Scholar] 12.Ernst B., Thurnheer M., Schmid S.M., Schultes B

Increase physical activity : Incorporating both aerobic exercise and resistance training can boost energy expenditure and preserve lean muscle mass

Tirzepatide, by contrast, activates both GLP-1 and GIP receptorsa dual action that amplifies satiety, reduces appetite-driven behavior, and may increase the body's calorie-burning capacity

These medications take this natural process a step further