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Description of Sponsor-Submitted Indirect Treatment Comparison The ITC included randomized trials of participants with a BMI of 27 kg/m 2 or greater and 1 weight-related comorbidity, ||| || ||| ||||| || ||||||| |||| |||||||||||||| ||||||||||||||, or BMI of 30 kg/m 2 or greater without weight-related comorbidities

Ethical and Practical Considerations: If your study involves a larger cohort where ease of administration is paramount, and you're willing to account for potentially lower or more variable bioavailability, an oral formulation might be explored

Rapid caloric restriction can affect serotonin production, since the amino acid tryptophan (a serotonin precursor) comes from dietary protein

38,71 Lanifibranor is a pan-PPAR agonist

Glucagon-like Peptide-1 receptor agonists use does not increase the risk for acute pancreatitis and is associated with lower complications in patients with type 2 diabetes who develop acute pancreatitis: a multicenter analysis