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Description
supplements GLP-1 medications like semaglutide ( Ozempic and Wegovy) and tirzepatide ( Zepbound and Mounjaro) are FDA-approved prescription drugs specifically designed to manage type 2 diabetes and/or aid in weight loss

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230,231 GLP-1 RAs also have positive effects on endothelial function, including increasing nitric oxide production, allowing for increased blood flow, decreasing vascular stiffness, and providing nutrients that are delivered to a specific repair area

The model included the following covariates: age, most recent hemoglobin A1c (if available), overweight/obesity status, body mass index (BMI), hypertension, ischemic heart disease, obstructive sleep apnea, hyperlipidemia, hypercholesterolemia, and prior therapy with antidiabetic agents (including sodium-glucose cotransporter 2 (SGLT2) inhibitors, dipeptidyl peptidase 4 (DPP-4) inhibitors, thiazolidinediones, alpha-glucosidase inhibitors, sulfonylureas, metformin, insulins, and other blood glucose-lowering drugs), as shown in Supplementary Table 1
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