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"Mensen die echt obesitas hebben er iets aan willen doen, moeten contact opnemen met de huisarts of de behandelend specialist", zegt de internist

The GLP1R rs6923761 variant affects how efficiently your GLP-1 receptors bind and activate when tirzepatide attaches, potentially shifting your dose-response curve

Heartburn specifically affected roughly 15% of patients, indicating it is a frequent side effect whose severity often rises with higher doses or overlapping risk factors

All of these side effects tend to be most common when you first start taking the medication or if your dose has been increased

None of this suggests that Retatrutide is a standalone solution or that body recomposition becomes effortless

doi: 10.3389/fendo.2021.652628