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They argued that selectivity would improve safety while still providing acceptable efficacy

To Cite: McIntyre RS

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The infection becomes sepsis when that response becomes excessive, harmful, disbalanced and leads to systemic inflammation, probably due to immunosuppression (5)

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GIP is best known for its ability to act on islets, where it regulates blood glucose levels by stimulating the secretion of insulin or glucagon (Christensen et al., 2011) and exerts its hypoglycemic effect by stimulating the G subunit, which in turn activates the adenosineadenylate cyclase (AC)cAMP-PKA signaling pathway when GIP binds to its receptor