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doi: 10.1111/dom.12902

Prolonged inhibition of DPP may prevent the formation of GLP-1 (9-36) amide, and might ultimately augment oxidative stress in the heart, vasculature, and liver, and promote hepatic glucose production, which would be undesirable in the treatment of obesity-related diabetes

However, metformin is oral, inexpensive, and has an extensive safety record, making it the preferred initial therapy

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While many customers report reduced cravings and improved digestion, others note little change, even after consistent use