article on alcohol and tobacco How Smoking Increase Your Risk of Esophageal Cancer Pattern and determinants of alcohol
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114.Pankow JF, Tavakoli AD, Luo W, Isabelle LM

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References Deaths Map: GBD 2019 Risk Factors Collaborators

In order to attract new customers, tobacco companies add chemicals to improve the flavor of the smoke and reduce harshness on the throat

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[1] 7080% of nicotine is metabolized by the liver, primarily into cotinine