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As Case 2 demonstrated, a patient may tolerate one drug in the class (semaglutide) but not another (tirzepatide), suggesting the reaction may be specific to certain agents or their unique pharmacologies

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Across the PIONEER trials around 1523% of patients experienced nausea with orally administered semaglutide 14 mg, and approximately 715% of patients on 14 mg orally administered semaglutide discontinued the trial

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Observational studies, which inherently harbor a heightened susceptibility to bias, similarly manifest diminished incidence rates for thyroid carcinoma, with effect estimations evincing incongruities across diverse investigations

Semaglutide not only consistently reduces energy intake (Blundell et al., 2017) but also achieves substantial weight loss, up to approximately 15% in individuals who are overweight or obese (Wilding et al., 2021)