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Massachusetts Lawmakers Propose Higher Tobacco Taxes Despite Record-Low Smoking Rates Lindsey Stroud Oct 9, 2025 4 min read Key Points: Legislation Introduced: Massachusetts lawmakers filed S.2020 and H.3074 (An Act Protecting Youth from Nicotine Addiction) to raise excise taxes on cigarettes, cigars, and smoking tobacco

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PLoS One 2018;13: e0206937

For boys, tobacco use was higher, with 16.4 % reporting usage in 2011 , dropping to 10 % in 2016

Therefore, in addition to exposure doses that tend to mimic the real-life conditions of e-cigarette use, unrealistically high doses can also be used without being fundamentally objectionable if the ultimate goal is to demonstrate dose-dependent effects that are very helpful in terms of elucidating mechanistic aspects of the toxicological process, even though such doses would neither be applicable nor would make sense in in vivo studies, and thus require special attention when interpreting the results