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Diabetologia 44:20182024 Kazda CM, Ding Y, Kelly RP et al (2016) Response to comment on Kazda et al

Motor disturbances/hypoactivity Another concern with therapies targeting the mesolimbic system is that the behavioral outcomes obtained are not specific to ingestive behavior and mediated via a general increase or decrease in physical activity

Ozempic activates specific receptors in the brain that regulate appetite and food intake

This is legally distinct from therapeutic supply under the TGA's regulatory framework

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PPAR signaling and metabolism: the good, the bad and the future