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What about Ghrelin and Leptin

P., Rath G., Mathur S., Bhatnagar D., Ralhan R

Early clinical trials in diabetic patients have indicated that GLP-1RAs treatment is associated with improvements in health-related quality of life and well-being compared with insulin and sulfonylureas.174176 A notably comparable study is the population-based cohort analysis by Gamble et al,174 which utilized UK databases to assess the incidence of new-onset depression or self-harm among new users of GLP-1RAs and dipeptidyl peptidase-4 inhibitors relative to sulfonylureas

Clinical trials have demonstrated its effectiveness in significantly reducing body fat while offering additional benefits such as improved cognitive function and mood, though potential side effects like dry mouth and increased heart rate require medical supervision

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The most frequently reported side effects include nausea, vomiting, diarrhea, and constipation