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Neurodegeneration and Stroke After Semaglutide and Tirzepatide in Patients With Diabetes and Obesity. JAMA Network Open

Understanding both common and severe reactions can help in making informed decisions about its use

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BMJ 29(372):n71 Crocker TF, Lam N, Jordo M, Brundle C, Prescott M, Forster A et al (2023) Risk-of-bias assessment using Cochranes revised tool for randomized trials (RoB 2) was useful but challenging and resource-intensive: observations from a systematic review

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The STEP trials (conducted over 68 weeks) demonstrated that people achieved 1522% total body weight reduction when taking semaglutide alongside lifestyle changes
