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28 Another advert by Ardath similarly advertised cigarettes as a fashionable thing

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A study shows that over five years, the average nicotine strength in an e-cigarette increased from 1.7% to 5%, which is double the amount of nicotine you inhale from a pack of cigarettes

This primary brain injury can be attributed to the activation of secondary injury pathways that include ionic imbalance, oxidative stress, excitotoxicity, mitochondrial dysfunction, inflammation, and BBB breakdown (Dirnagl et al., 1999