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The mechanism of CGA in regulating glucose metabolism and lipid metabolism can be summarized as follows: (1) CGA acts on the expression of enzymes and genes related to glucose metabolism improves insulin sensitivity, thus, alleviates the development of diabetes

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By rapidly replenishing myocardial energy stores via the PRPP surge, D-ribose may help the heart pump more efficiently, maintain better diastolic compliance, and better tolerate the low blood flow states characteristic of orthostatic intolerance

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Furthermore, FMO3 is regulated by farnesoid X receptor (FXR), a nuclear receptor activated by bile acid ( TMAO levels were significantly associated with body mass index (BMI) in healthy adults with different risk factors (Wang et al., 2016), and studies in humans and mice have shown that plasma TMAO levels increased with ageing (Wang et al., 2014
