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This is likely because the brain quickly adapts to the elevated dopamine levels which results in the users chasing the same effects with higher doses

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Despite these estimations, in the world, the use of smokeless tobacco is quite popular in most countries, with a rising trend in the United States of America (USA) 2,3 and an uncontrolled consumption rate in Nigeria

It exposes the brain to free radicals, which harms neurons and causes inflammation, speeding up the ageing process

[DOI] [PubMed] [Google Scholar] Temburni MK, Blitzblau RC, Jacob MH