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Cancer Treat Rev

2013c;38(8):125970

10.1007/s12630-023-02549-5 [DOI] [PubMed] [Google Scholar] 36.Nersessian RSF, da Silva LM, Carvalho MAS, Silveira SQ, Abib ACV, Bellicieri FN et al (2024) Relationship between residual gastric content and peri-operative semaglutide use assessed by gastric ultrasound: a prospective observational study

Overall satisfaction with the schedule

GLP-1 Receptor Activation Mechanism Increases insulin secretion in response to glucose, preventing blood sugar spikes Reduces glucagon production, stabilizing blood sugar levels Slows gastric emptying, helping patients feel fuller for longer Regulates appetite and reduces cravings, leading to lower caloric intake Supports long-term fat loss and metabolic stability By addressing multiple metabolic pathways, Semaglutide supports sustainable weight management and improved glucose control

Thus, cotadutide, via direct hepatic (GcgR) and extrahepatic (Glp-1R) effects, exerts multifactorial improvement in liver function and is a promising therapeutic option for the treatment of steatohepatitis