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Conclusion Synthetic nicotine is a synthesized version of nicotine that is not extracted from tobacco leaves

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Although the epigenetic mechanisms by which benzo[a]pyrene and nicotine-induced alterations can be vertically transmitted has not been resolved, smoking-induced abnormal protamination may cause alterations in the methylation pattern of CpG in the promoter regions of DNA in the offspring of smokers [161]

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Heron J, Hickman M, Macleod J, Munafo MR